New Methods for C-C Bond Construction
Chemexpress Luigino Troisi of the University of Salento found (Tetrahedron Lett. 2010, 51, 371. DOI: 10.1016/j.tetlet.2009.11.023) that a variety of primary and secondary amines could be coupled with a benzylic halide…
Heteroaromatic Construction: The Fukuyama Synthesis of Tryprostatin A
Alessandro Palmieri of the University of Camerino developed (Synlett 2010, 2468. DOI: 10.1055/s-0030-1258031) the condensation of a nitro acrylate 1 with a 1,3-dicarbonyl partner 2 to give the furan 3.…
Total Synthesis of the Galbulimima Alkaloid GB 13
Lew Mander of the Australian National University recently reported (J. Am. Chem. PMID:33679749 Soc. 2003, 125, 2400.DOI: 10.1021/ja029725o)the total synthesis of the pentacyclic alkaloid GB 133, which had been isolated…
Functionalization and Homologation of Alkenes
Masahito Ochiai developed ( 2008, March 24) the iodosobenzene-mediated cleavage of alkenes to keto aldehydes. PMID:23557924 Thottumkara K. Vinod of Western Illinois University described (Org. Lett. 2010, 12, 5640. DOI:…
Metal Mediated C-C Ring Construction: The Nevado Route to (-)- Frondosin A
Barry M. 6-Bromo-3-chloroisoquinoline structure Trost of Stanford University generated (J. Am. Chem. Soc. 2011, 133, 4766. DOI: 10.1021/ja200971v) a β-keto carbene from the propargyl alcohol 1, leading to the cyclopropane…
Enantioselective Preparation of Alkylated Stereogenic Centers
Jon D. Stewart of the University of Florida established (Chem. Commun. 2010, 46, 8558. DOI: 10.1039/C0CC03119D) a scalable enzymatic reduction of geranial 1 to citronellal 2. Andreas S. Bommarius of…
C-O Ring Construction: (-)-Sclerophytin A (Morken), (+)-Dictyosphaeric Acid
(Taylor), Goniothalesdiol A (Xie/She), (-)-7-Deoxyloganin (Lupton), (-)-Apicularen A (Uenishi)L-783, 277 (Banwell) In the course of a synthesis of (-)-Sclerophytin A (3), James P. Morken of Boston College showed (J. Am.…
Ts, D. M.; Myagkota, S. V. J. Phys. Chem. Solids 2008, 69, 2520-
Ts, D. M.; Myagkota, S. V. J. Phys. Chem. Solids 2008, 69, 2520-2526. (18) Stoumpos, C. C.; Malliakas, C. D.; Kanatzidis, M. G. Inorg. Chem. 2013, 52, 9019-9038. (19) Babin,…
:0 i18:0 18:0 P MUFA 16:1n-7c 17:1n-8ca 18:1n-9c 18:1n-7c
:0 i18:0 18:0 P MUFA 16:1n-7c 17:1n-8ca 18:1n-9c 18:1n-7c 20:1n-9c 24:1n-9c P PUFA P n-3 20:5n-3 (EPA) 22:6n-3 (DHA) 22:5n-3 P n-6 20:4n-6 (AA) 22:5n-6 22:4n-6 n-3/n-6 39.1 (0.7) 13.8…
Substituted Benzenes: The Piers/Lau Synthesis of Hamigeran B
Govindasamy Sekar of the Indian Institute of Technology, Madras developed (Chem. Commun. 2011, 47, 5076. DOI: 10.1039/C1CC10568J) an environmentally-friendly procedure for the amination of 1 to 2. Jens-Uwe Peters of…