Unction inside the NaV1 channel in C. finmarchicus is accomplished by way of both option splicing and gene duplication. This diversity of transcripts for voltagegated sodium channels helps explain why…
O their matching orthologues inside the other tetraploid, G. barbadense (.98 at the aa level). The deduced proteins varied from 514 to 582 amino acids and all clustered within the…
Aspalathin (Minehan), (+)-Varitriol (Ghosh), Aspercyclide A (Spivey), Etnangien (Menche) (+)-Pachastrissamine (3), also known as Jaspine B, induces apoptosis in melanoma cells by a caspase-dependent pathway. Nobutaka Fujii and Hiroaki Ohno…
(+)-Subincanadine F (Li), (±)-Strychnine (Reissig), (-)-Virginiamycin M2 (Panek) Aldehydes such as 1 are readily available by direct enantioselective chlorination. Robert Britton of Simon Fraser University found (Org. Lett. 2010, 12,…
Adriaan J. Minnaard and Ben L. Feringa of the University of Groningen devised (J. Azido-PEG2-CH2COOH Price Am. Chem. Soc. 2010, 132, 14349. DOI: 10.1021/ja105704m) what promises to be a general…
Asymmetric epoxidation of a prochiral alkene is an appealing process because two stereogenic centers are established in the course of the reaction. Often, the starting alkene is inexpensive. 1203499-17-5 Order…
The complex polycyclic structure of N-Methylwelwitindolinone D Isonitrile (3) was assigned in 1999. The welwitinines show an intriguing range of biological activity, including reversal of P-glycoprotein-mediated multidrug resistance in human…
The Hajos-Parrish cyclization was a landmark in the asymmetric construction of polycarbocyclic natural products. PMID:24220671 Impressive at the time, the proline-mediated intramolecular aldol condensation proceeded with an ee that was…
The periwinkle-derived alkaloids vinblastine (2a) and vincristine (2b) are still mainstays of cancer chemotherapy. The more complex half of these dimeric alkaloids, vindoline (1), presents a formidable challenge for total…
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