S (Han et al., 2012a), ataxia (Kalume et al., 2007), and circadian rhythm disruption (Han et al., 2012b). In close correlation together with the human disease, DS mice create normally…
Eostasis Impact on Airway Functionintroduced into the left lung below a continuous stress of 20 cm H2O. The lungs and also the heart have been dissected en block and cooled…
David B. Cordes of Pacific University reported (Tetrahedron Lett. 2009, 50, 1817. DOI: 10.1016/j.tetlet.2009.02.014) a simple combination of NaBH4 and Pd/C that reduced the alkene 1 to 2. This could…
We last reviewed organic synthesis applications of the Grubbs reaction on April 19, 2004. The (relatively) robust nature of the commercially-available catalyst and its commercial availability have spurred the expanding…
Ming Yan of Sun Yat-sen University, Guangzhou, optimized (Synlett 2010, 266. DOI: 10.1055/s-0029-1218570) the organocatalyzed addition of 2 to a cyclic enone 1, establishing the cyclopropane 3 with high diastereo-…
Xiang-Ping Hu and Zhuo Zheng of the Dalian Institute of Chemical Physics developed (Org. Lett. 2009, 11, 3226, DOI: 10.1021/ol9012469; J. Org. Chem. 2009, 74, 9191, DOI: 10.1021/jo901619c) a family…
SC-Δ13-9-IsoF (Taber), Brevisamide (Panek, Lindsley, Ghosh), Gambierol (Mori) The challenge of controlling the relative and absolute configuration of highly substituted cyclic ether-containing natural products continues to stimulate the development of…
Huanfeng Jiang of the South China University of Technology showed (J. Org. 5-Bromo-2-(tert-butyl)pyridine Purity Chem. 2010, 75, 966. DOI: 10.1021/jo902375k) that an alkynoate 1 could be condensed with a 1,3-dicarbonyl…
Lee), (-)-Amphidinolide K (Eun Lee), Norhalichondrin B (Phillips) A variety of antibiotics and immune-suppressive agents contain extended arrays of all-(E)-polyenes. Samir Bouzbouz of CNS Rouen and Janine Cossy of ESPCI…
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