D arabinose accounted for the remaining 30 ofBacterioplankton-specific development prices have been drastically larger only within the Amansia amendments (1.1 1 per day), whereas other treatments and controls ranged from…
An tissues (MTC panel human I, Clontech) was amplified by PCR applying ARSK-specific primers (forward primer five -TTA ATT CAT CTG GAT CCG AGG AAA G-3 and reverse primer five…
(-)-Nakiterpiosin (3), isolated from the thin encrusting sponge Terpios hoshinota, has an IC50 against murine P388 leukemia cells of 10 ng/mL. Chuo Chen of UT Southwestern Medical Center developed (J.…
(+)-Hirsutellone B (3), isolated from the insect pathogenic fungus Hirsutella nivea BCC 2594, shows good activity (MIC = 0.78 μg/mL) against Mycobacterium tuberculosis. Approaching the synthesis of 3, K. Val-cit-PAB-OH…
The total synthesis of lupeol was one of the crowning achievements of the Robinson annulation/reductive alkylation approach to stereocontrolled polycarbocyclic construction developed by Gilbert Stork (J. Am. Chem. Soc. 1971,…
Briarellin F (4) is an elegant representative of the complex polycyclic ethers produced by soft corals such as Briareum abestinum. Larry E. Overman of the University of California, Irvine developed…
(-)-4-Hydroxydictyolactone (3), representative of the cyclononene xenicanes isolated from the Dictyotacae algae, readily isomerizes thermally to the more stable (Z)-6,7-isomer. Attempts to directly form this strained ring system appeared to…
(-)-Nakadomarin A (4), isolated from the sponge Amphimedon sp. off the coast of Okinama, shows interesting antifungal and antibacterial activity. The key step in the total synthesis of 4 reported…
Bioreductions and biooxidations, although they can be highly selective, have often been limited by the requirement for expensive reducing or oxidizing biological cofactors. PMID:23626759 Wolfgang Kroutil of the University of…
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