Ryoichi Kuwano of Kyushu University showed (J. Am. 1-Hydroxyhept-6-yn-3-one structure Chem. Formula of 4-Bromo-3-fluoropicolinaldehyde Soc. 2008,130, 808. DOI: 10.1021/ja7102422)that diastereomerically and enantiomerically pure pyrrollidines such as 2 could be prepared…
Although methods both for reduction and for oxidation are well developed, there is always room for improvement. PMID:24059181 While ketones are usually reduced using metal hydrides, hydrogen gas is much…
Mohammad Navid Soltani Rad of Shiraz University of Technology has shown (Tetrahedron Lett. 2007, 48, 6779.DOI: 10.1016/j.tetlet.2007.07.091)that with tosylimidazole (TsIm) activation in the presence of NaCN, primary, secondary and tertiary…
The group of Christian Wolf from Georgetown University, Washington, has reported on the synthesis of benzophenone and acetophenone derivatives via the Suzuki-type cross-coupling of aromatic and aliphatic acyl chlorides with…
An impressive array of new catalysts for enantioselective homologation have been reported. Carlos F. Barbas III of Scripps/La Jolla has found (Angew. Chem. Int. Ed. 2007, 46, 5572. DOI: 10.1002/anie.200701269)that…
The group of Peter Andreana from Wayne State University, Michigan, has developed a one-pot two-step synthesis of regiochemically differentiated 1,4-benzodiazepin-3-ones (Org. PMID:24633055 Lett. 2008, 10, 4541. (6S)-Hexahydro-1,4-oxazepin-6-ol In stock DOI:…
An extensive optimization study toward the synthesis of 6-heterocyclic substituted 2-aminoquinolines via Buchwald-Hartwig amination of 6-bromo-2-chloroquinoline withcyclic amines was conducted by the group of Simon Pyke from the University of…
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