Strained three- and four-membered rings can be used to constructlarger rings. The release of the strain energy facilitates bond formation, and the stereochemistry of the small ring can be transmitted…
Chan-Mo Yu of Sungkyunkwan University, Suwon, has developed (Angew. Chem. Int. 3-Azidopropanoic acid uses Ed. 2006, 45, 1553. PMID:24580853 DOI: 10.1002/anie.200503863)a powerful strategy for assembling arrays of stereogenic centers, using…
Usually, aryl-aryl bonds are formed by the coupling of two functionalized aromatic carbons. Formula of Mesityl-λ3-iodanediyl diacetate Having both of the aromatic carbons functionalized is not always necessary. It is…
Alkenes are among the least expensive of organic functional groups. They are easily incorporated into a growing molecule, and are stable to many of the reagents that transform other functionality.…
Intramolecular carbene insertion (e.g. 1 -> 3) has long been a useful method for ring construction. Masahisa Nakada of Waseda University in Tokyo now reports (J. Am. Chem. Soc. Buy5-Methoxyquinazolin-4(3H)-one…
The tetracyclic alkaloid quinine 1 and the diastereomeric alkaloid quinidine 2 share a storied history. Eric Jacobsen of Harvard recently completed (J. PMID:25027343 Buy2-Chloro-1H-indole Am. Chem. Soc. 2004, 126, 706.DOI:…
Alkene and alkyne metathesis, well-developed synthetic methods, are now often employed in natural product synthesis. The total syntheses outlined here are noteworthy for their creative application of these reactions. Buy7-Amino-4-bromoisoindolin-1-one…
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