T or chiA/chiALF82 infected HEK293 cells 24 hours post infection, as in comparison to that from uninfected cells . In contrast, the remaining mutant strains (LF82chiA, chiA/chiAK12, chiA/chiALF825MU or 52D11)…
Er amounts. In summary, the aforementioned results reveal that the metalcatalyzed and the organocatalytic procedures have a different behavior depending upon the substitution pattern. Hence, whereas the metalcatalyzed process afforded…
The prochiral aziridine 1 is easily prepared from cyclooctene. Paul Müller of the University of Geneva has shown (Helv. Chim. Buy362522-50-7 Acta 2004, 87, 227. DOI: 10.1002/hlca.200490010)that metalation of 1…
While N-heterocycles have dominated pharmaceutical synthesis from its inception, the increasing facility with which complexcyclic ethers can be assembled suggests that such cyclic ethers could also be suitable pharmaceutical platforms.…
Imre Pápai and Tibor Soós of the Institute of Organic Chemistry, Budapest prepared the oxetane 3 by the relay ring-closing methathesis of the alkene 1 with the diene 2 (Angew.…
Joshua D. Sieber of Virginia Commonwealth University used a Cu catalyst to mediate the assembly of the protected amino alcohol 3 by the addition of the allenamide 2 to the…
Xiongjie Jin and Kyoko Nozaki of the University of Tokyo established an effective protocol for the hydrogenation of an ester 1 to the corresponding hydrocarbon 2 (J. Am. Chem. Soc.…
Qiwei Lang, Gen-Qiang Chen and Xumu Zhang of the Southern University of Science and Technology achieved high ee in the reduction of the readily available lactol 1 to the lactone…
Petromyroxol (3) was isolated from > 106 liters of sea water conditioned with larval sea lamprey, Petromyzon marinus. Rodney A. Fernandes of the Indian Institute of Technology Bombay assembled the…
Many of the five- and six-carbon sugars, although well known, are rare, and too expensive to be used as chiral pool starting materials. David MacMillan of Caltech in an elegant…
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